过去一年中添加的文章，按日期排序
Selective Degradation of Aggregated Tau Protein Via Vectored Nanobody-TRIM21 RING Fusion Constructs
J Benn - 2024 - repository.cam.ac.uk
5 天前 - … degraded by the intracellular Fc receptor and E3 ubiquitin … fused to the E3 ubiquitin
ligase domain of TRIM21. This … Further clinical trials using antibodies targeting alternative …
ligase domain of TRIM21. This … Further clinical trials using antibodies targeting alternative …
Abstract PO4-18-03: Combined Treatment with Pyrotinib and Chrysin Synergistically Improve the Autophagy Level in HER2-Positive Breast Cancer by Regulating the …
T Luo, X Zhong, P He, D Zheng, Y Cheng, K Zhu - Cancer Research, 2024 - AACR
7 天前 - … chrysin induced ubiquitination and G6PD degradation by … k Ubibrowser database
predicting the E3 ubiquitin ligases … ubiquitin antibody. n Dual-luciferase report verifying the …
predicting the E3 ubiquitin ligases … ubiquitin antibody. n Dual-luciferase report verifying the …
Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B Cell Lymphoma
D Hodson - 2024 - repository.cam.ac.uk
14 天前 - … V) is an antibody-drug conjugate … E3 ubiquitin ligase that is recurrently inactivated
in germinal center derived lymphomas. We reveal how KLHL6 targets CD79B for degradation …
in germinal center derived lymphomas. We reveal how KLHL6 targets CD79B for degradation …
DRUGGING THE UNDRUGGABLE PROTEIN TYROSINE PHOSPHATASES FOR CANCER THERAPY: EXPECTED AND UNEXPECTED
Y Miao - 2024 - hammer.purdue.edu
18 天前 - … or antibodies achieved many successes for various indications. For example,
targeting epidermal growth factor receptor for … and proteasome degradation. Compared with the …
targeting epidermal growth factor receptor for … and proteasome degradation. Compared with the …
Discovery of mutation-independent EGFR degrading bispecific antibodies that suppress tumor growth in preclinical tumor models
48 天前 - … ) and transmembrane E3 ligases, and KineTACs (cytokine receptor-targeting
chimeras) … cytokine receptors to degrade extracellular POIs. These bispecific antibody degrader …
chimeras) … cytokine receptors to degrade extracellular POIs. These bispecific antibody degrader …
Proteolysis targeting chimera (PROTAC)-driven internalization of antibodies targeting oncogenic cell surface receptors
EJ Tolosa, L Yang, J Ayers-Ringler, J Mallareddy… - Cancer Research, 2024 - AACR
48 天前 - … for many cell surface targets, limiting the … targets by inducing proximity with E3
ligases. The proteasome then recognizes the poly-ubiquitin chains and degrades these targets. …
ligases. The proteasome then recognizes the poly-ubiquitin chains and degrades these targets. …
Telisotuzumab vedotin (Teliso-V)-mediated c-Met internalization, endolysosomal trafficking, and potent cytotoxic activity are unaffected by MET exon-14 skipping …
I Batth, R Pandoy, S Khaja, D Maji, T Uziel… - Cancer Research, 2024 - AACR
48 天前 - … a c-Met (MET protein) antibody coupled to the microtubule … , Teliso-V must first
undergo receptor internalization and … and degradation depend on the E3 ubiquitin ligase Casitas …
undergo receptor internalization and … and degradation depend on the E3 ubiquitin ligase Casitas …
Single-Domain Antibody-Based Protein Degrader for Synucleinopathies
56 天前 - … α-syn ubiquitination and proteasomal degradation. Our … of the E3 ubiquitin ligase
TRIM21 is crucial for enabling … Sigurdsson, Two novel Tau antibodies targeting the 396/404 …
TRIM21 is crucial for enabling … Sigurdsson, Two novel Tau antibodies targeting the 396/404 …
Mechanisms of TRIM21-directed intracellular degradation
T Rhinesmith - 2024 - repository.cam.ac.uk
98 天前 - … The cytosolic antibody receptor TRIM21 has been studied … to antibody binding,
TRIM21 is a ubiquitin E3 ligase, an … into the targeted protein degradation technology Trim-Away, …
TRIM21 is a ubiquitin E3 ligase, an … into the targeted protein degradation technology Trim-Away, …